CAS 110-54-3 · K-REACH · Republic of Korea

n-Hexane under K-REACH

C6H14 · 正己烷

Status: Registered. n-Hexane is registered under K-REACH. **Korea TCCA Toxic Chemicals list status: verify the current TCCA Toxic Chemicals list entry against the most recent National Institute of Chemical Safety (NICS) toxic-chemical database before relying; n-hexane's Repr. 2 + STOT RE 2 peripheral neuropathy hazard profile may trigger TCCA scheduling. n-Hexane peripheral-neuropathy occupational exposure has historical regulatory salience in Korea following the 2005 LCD-factory Chinese-migrant-worker n-hexane peripheral-neuropathy outbreak in Suwon (verify historical context against Korean Ministry of Labour archives before relying on specifics)**. NOT on Korean Drug Management Act precursor list. NO active Korean AD/CVD case on Chinese-origin n-hexane currently (verify against https://www.kita.org/ or Korea Trade Commission filings before invoicing). Korea has substantial domestic n-hexane production (typically refinery-integrated at SK Innovation, GS Caltex, S-OIL, Hyundai Oilbank); structurally balanced producer-importer. KCFTA preferential zero-duty applies for Chinese-origin imports. IARC Group 3.

K-REACH treats n-hexane as a registered substance with **TCCA Toxic Chemicals scheduling potentially applicable** (verify against NICS database; 2005 Suwon LCD-factory n-hexane peripheral-neuropathy outbreak historically salient). Korea has substantial domestic refinery-integrated production at SK Innovation + GS Caltex + S-OIL + Hyundai Oilbank; balanced producer-importer. NO active Korean AD/CVD case. **n-Hexane distinguishing pattern across all 5 regimes**: Production from light naphtha steam-cracker C6 fraction or refinery raffinate / hydrotreater stream (specialty-grade requires fractional distillation to isolate n-isomer from 2-methylpentane + 3-methylpentane + cyclohexane + methylcyclopentane co-products) + completes aliphatic-solvent chain alongside cyclohexane batch 56 (C6 cycle vs C6 chain) + edible oil extraction solvent ~50% (soybean + cottonseed + canola) plus printing inks plus adhesive solvent plus polymerisation solvent (LDPE + PP) plus gasoline blending plus laboratory solvent downstream chains + moderate hazard profile across regimes (Repr. 2 + STOT RE 2 peripheral neuropathy from 2,5-hexanedione metabolite + Asp. Tox. 1 + Flam. Liq. 2 + Aquatic Chronic 2 harmonised CLP) + IARC Group 3 per Volume 71 (1999) + US OSHA PEL 500 ppm but NIOSH REL 50 ppm (ACGIH TLV 50 ppm with skin notation) + California Prop 65 listed 15 December 2017 for Male Reproductive Toxicity + Australian Safe Work WES 20 ppm + Korean 2005 Suwon LCD-factory outbreak historical salience + China GBZ 2.1-2019 PC-TWA 100 mg/m3 + FDA 21 CFR 173.270 indirect food additive solvent for spice + hops + oilseed extraction.