CAS 26471-62-5 · REACH · European Union

TDI mixed isomers (toluene diisocyanate, 80:20 + 65:35 blends) under REACH

C9H6N2O2 · 甲苯二异氰酸酯

Status: Restricted. TDI mixed isomers (CAS 26471-62-5) covers 2,4-TDI (CAS 584-84-9) + 2,6-TDI (CAS 91-08-7) at 80:20 (TDI 80) or 65:35 (TDI 65) ratios. Fully registered under REACH at the highest tonnage band (>1,000,000 tonnes/year). **Distinguishing pattern: closes toluene batch 20 chain (downstream TDI product) + Acute Tox. 2 inhalation (H330 "fatal if inhaled"; significantly more toxic than MDI batch 30 Acute Tox. 4) + Resp. Sens. 1 + same Annex XVII Restriction 56 diisocyanate training requirement as MDI batch 30 + Wanhua Chemical Yantai TDI leadership + flexible polyurethane foam primary downstream (different end-use mix from MDI which is rigid PU dominant) (NEW combined).** Reg (EC) 1272/2008 harmonised: Carc 2 + Acute Tox. 2 inhalation (more toxic than MDI batch 30) + Resp. Sens. 1 + Skin Sens. 1 + Skin Irrit. 2 + Eye Irrit. 2 + STOT SE 3 + STOT RE 2 + Aquatic Chronic 3.

TDI mixed isomers is fully REACH-registered with **heavier hazard profile than MDI batch 30**: Acute Tox. 2 inhalation (H330 "fatal if inhaled"; vs MDI Acute Tox. 4). The dominant downstream finished-product compliance layer is **Annex XVII Restriction 56 EU-wide diisocyanate training requirement** (same as MDI batch 30; effective 24 February 2022). NOT SVHC despite Carc 2 (kept off because of essential industrial use). NO active EU AD case. Major Chinese producers: **Wanhua Chemical Yantai (a leading TDI producer with integrated upstream toluene batch 20 plus DNT plus TDA chain; verify the most recent TDI nameplate against the Wanhua Chemical investor site before quoting world-leading rank)**, Sinopec Yangtze + Sinopec Shanghai, Cangzhou Dahua TDI Chemical (Hebei), BASF Shanghai + BASF Chongqing. China dominates global TDI capacity (~50%, ~3-4 Mt/yr). Production: toluene batch 20 + nitric acid + sulfuric acid batch 2 → DNT → TDA → phosgenation → TDI. **Closes the toluene batch 20 chain**. End-use mix differs from MDI batch 30: **flexible polyurethane foam (~70%)** is dominant for TDI vs rigid PU foam dominant for MDI.

Listing and threshold

Substance TDI mixed isomers (toluene diisocyanate, 80:20 + 65:35 blends) (CAS 26471-62-5), C9H6N2O2
Regime EU Regulation (EC) No 1907/2006: Registration, Evaluation, Authorisation and Restriction of Chemicals
Jurisdiction European Union (EU-27 plus EEA: Iceland, Liechtenstein, Norway)
Status Restricted
Tonnage threshold Registration required for any importer or manufacturer placing >1 t/year on the EU market

Classifications under this regime

  • Harmonised CLP classification: Carc. 2 (H351), Acute Tox. 2 inhalation (H330, "fatal if inhaled"; more toxic than MDI batch 30 Acute Tox. 4), Skin Irrit. 2 (H315), Eye Irrit. 2 (H319), Resp. Sens. 1 (H334), Skin Sens. 1 (H317), STOT SE 3 (H335), STOT RE 2 (H373), Aquatic Chronic 3 (H412)
  • Signal word: DANGER
  • GHS pictograms: GHS06 (skull and crossbones), GHS08 (health hazard, sensitiser / target organ)
  • **IARC: Group 2B (possibly carcinogenic to humans) since 1986 IARC Monograph 39; reaffirmed in subsequent volumes** (verify Volume 39 plus the most recent reassessment volume against https://monographs.iarc.who.int/list-of-classifications)
  • NOT subject to Drug Precursors or Explosives Precursors scheduling
  • ADR / RID transport classification: Class 6.1 (toxic substance), UN 2078 (TDI), Packing Group II

Restrictions and conditions of use

  • NOT on REACH Annex XIV (Authorisation list)
  • NOT classified as SVHC
  • **Annex XVII Restriction 56 (Reg (EU) 2020/1149)**: same EU-wide industrial / professional diisocyanate training requirement as MDI batch 30; effective 24 February 2022 (verify the consolidated Restriction 56 text and TDI applicability against EUR-Lex https://eur-lex.europa.eu/eli/reg/2020/1149/oj before relying)
  • NO active EU AD case on Chinese-origin TDI currently
  • Carbon Border Adjustment Mechanism (CBAM): NOT in CBAM Phase 1 scope
  • EU Reg 10/2011 food-contact: TDI specific migration limit (SML "ND" non-detectable)

Importer obligations

A non-EU producer cannot register directly under REACH. The EU importer of record must hold a registration or rely on an Only Representative (OR). The dominant practitioner-facing layer is **Annex XVII Restriction 56 diisocyanate training requirement** (effective 24 February 2022; same as MDI batch 30). **Acute Tox. 2 inhalation (H330 "fatal if inhaled")** drives the heaviest workplace exposure-control overhead in the dataset alongside benzene batch 22 + formaldehyde batch 18 + EO batch 28 + butadiene batch 27. Major Chinese producers: **Wanhua Chemical Yantai (a leading TDI producer with integrated upstream toluene batch 20 plus DNT plus TDA chain; verify the most recent TDI nameplate against the Wanhua Chemical investor site before quoting world-leading rank)**, Sinopec Yangtze + Sinopec Shanghai, Cangzhou Dahua TDI Chemical (Hebei), BASF Shanghai + BASF Chongqing. EU domestic producers: BASF Ludwigshafen + BASF Tarragona, Covestro Brunsbüttel + Krefeld + Tarragona.

Required documents

  • REACH registration number on the EU side (registrant or OR-appointed)
  • Safety Data Sheet (SDS) compliant with REACH Annex II in destination Member State language(s) reflecting H315 / H317 / H319 / H330 / H334 / H335 / H351 / H373 / H412 classification
  • CLP-compliant labelling with GHS06 + GHS08 pictograms and DANGER signal word
  • Customs entry with HS code 292910 (TDI as monomeric form)
  • ADR consignment note for transport (Class 6.1, UN 2078, PG II)
  • **Annex XVII Restriction 56 diisocyanate training documentation** for downstream industrial / professional users

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • **Annex XVII Restriction 56 diisocyanate training requirement effective 24 February 2022** (same as MDI batch 30) is the dominant downstream finished-product compliance layer
  • **Acute Tox. 2 inhalation (H330 "fatal if inhaled")** drives heavier workplace exposure-control overhead than MDI batch 30 (which is Acute Tox. 4 inhalation). TDI is significantly more toxic than MDI
  • **Resp. Sens. 1** drives substantial workplace exposure-control overhead + occupational asthma surveillance (same as MDI batch 30)
  • NOT SVHC despite Carc 2 (kept off because of essential industrial use)
  • NO active EU AD case on Chinese TDI currently
  • Major Chinese producers: **Wanhua Chemical Yantai (a leading TDI producer with integrated upstream toluene batch 20 plus DNT plus TDA chain; verify the most recent TDI nameplate against the Wanhua Chemical investor site before quoting world-leading rank)**, Sinopec Yangtze + Sinopec Shanghai, Cangzhou Dahua TDI Chemical (Hebei), BASF Shanghai + BASF Chongqing. China dominates global TDI capacity (~50%, ~3-4 Mt/yr)
  • Production: toluene (batch 20) + nitric acid + sulfuric acid (batch 2) → DNT → TDA → phosgenation → TDI integrated route
  • End-use mix differs from MDI batch 30: **flexible polyurethane foam (~70%, mattress + furniture + automotive seat + textile)** is dominant for TDI vs rigid PU foam dominant for MDI; CASE elastomers (~15%); other (~15%)
  • Mixed isomer 80:20 TDI (TDI 80) is most common; 65:35 (TDI 65) for specific applications. Toluene + nitric acid + sulfuric acid feedstock chain economics flow through structurally

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for tdi mixed isomers (toluene diisocyanate, 80:20 + 65:35 blends), see the CAS 26471-62-5 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the tdi mixed isomers (toluene diisocyanate, 80:20 + 65:35 blends) cornerstone hub covers the full sourcing chain.

For the structure and history of REACH, see the REACH glossary entry.

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