CAS 56-81-5 · TSCA · United States of America

Glycerol (glycerine, propane-1,2,3-triol) under TSCA

C3H8O3 · 甘油

Status: Listed. Glycerol is on the TSCA Inventory and is currently listed as TSCA Active. Light-regulatory profile. NOT on EPA RMP threshold list. NOT on DEA scheduling. NOT on California Proposition 65 (verify against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before relying on negative listing). NOT on TRI Section 313 list. NO active US AD/CVD case on Chinese-origin glycerol currently (verify against https://access.trade.gov/ before invoicing). Section 301 List 3 25% additional duty applies on Chinese-origin glycerol (HS 290545 / 152000). FDA 21 CFR 184.1505 GRAS for food use (verify against ecfr.gov before relying); USP (United States Pharmacopeia) monograph applies for pharmaceutical-grade glycerol.

The US glycerol lane has **light regulatory profile**: NOT on TRI, Cal Prop 65, RMP, DEA. Section 301 List 3 25% additional duty applies. Major US domestic producers: Cargill, ADM, P&G Chemicals. US is structurally net-importer of premium-grade pharmaceutical glycerol.

Listing and threshold

Substance Glycerol (glycerine, propane-1,2,3-triol) (CAS 56-81-5), C3H8O3
Regime US Toxic Substances Control Act (TSCA), administered by EPA
Jurisdiction United States of America
Status Listed
Tonnage threshold CDR (Chemical Data Reporting) threshold: 25,000 lb (11,340 kg) manufactured or imported per site per year

Classifications under this regime

  • OSHA Hazard Communication Standard (HCS): not classified at industrial-grade
  • OSHA PEL: not specifically established
  • NIOSH REL: not specifically established
  • NOT subject to TSCA Section 6 Risk Evaluation
  • NOT on TSCA Section 5(a)(2) Significant New Use Rule list
  • NOT on EPA RMP threshold list
  • NOT on DEA List I or List II
  • NOT on California Proposition 65 list (verify against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before relying on negative listing)
  • NOT on TRI Section 313 list
  • DOT hazardous materials regulation (49 CFR 172.101): not regulated as DG
  • IARC: nitric acid itself is not separately classified; occupational exposure to strong-inorganic-acid mists containing sulfuric acid was classified IARC Group 1 (laryngeal cancer) in Monograph Volume 54 (1992) (verify the current classification and Monograph volume against https://monographs.iarc.who.int/list-of-classifications before relying on the inorganic-acid-mist read-across for nitric acid)
  • **FDA 21 CFR 184.1505 GRAS for food use; USP monograph for pharmaceutical-grade**

Restrictions and conditions of use

  • No TSCA-specific use restrictions for glycerol
  • OSHA-compliant SDS and workplace HazCom training required (light hazard)
  • NO active US AD/CVD case on Chinese-origin glycerol currently
  • Section 301 List 3 25% additional duty applies on Chinese-origin glycerol (HS 290545 / 152000)
  • FDA 21 CFR 184.1505 GRAS approval for food use
  • USP pharmacopoeia monograph compliance for pharmaceutical-grade lots

Importer obligations

TSCA is a self-certification regime. The dominant practitioner-facing layer is Section 301 List 3 25% additional duty + FDA + USP grade-specification compliance for food + pharmaceutical-grade lots. NO active AD/CVD case. Major US domestic producers: Cargill (Eddyville Iowa biodiesel-byproduct), ADM / Archer Daniels Midland (Decatur Illinois biodiesel-byproduct), P&G Chemicals (Cincinnati Ohio soap-byproduct), Dow Chemical (Plaquemine Louisiana epichlorohydrin synthesis route legacy).

Required documents

  • TSCA Section 13 Import Certification statement on customs entry
  • OSHA-compliant SDS
  • Customs entry CBP Form 7501 with HS code 290545 or 152000 and Section 301 List 3 25% duty applied
  • FDA 21 CFR 184.1505 GRAS conformity declaration for food-grade lots
  • USP pharmacopoeia conformity declaration for pharmaceutical-grade lots

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • **Light-regulatory profile**: NOT on TRI, NOT on Cal Prop 65, NOT on RMP, NOT on DEA, NO active AD
  • Section 301 List 3 25% additional duty applies; only tariff-stack layer
  • Major US domestic producers: Cargill (Eddyville Iowa biodiesel-byproduct), ADM (Decatur Illinois biodiesel-byproduct), P&G Chemicals (Cincinnati Ohio soap-byproduct)
  • US is structurally net-importer of premium-grade pharmaceutical glycerol from European + Asian supply

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for glycerol (glycerine, propane-1,2,3-triol), see the CAS 56-81-5 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the glycerol (glycerine, propane-1,2,3-triol) cornerstone hub covers the full sourcing chain.

For the structure and history of TSCA, see the TSCA glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

Read next

Cross-jurisdiction profile and sourcing references

Referenced in

4 pages across the Sourzi moat

This term shows up in 4 regulatory pages. Sample backlinks per content type below.

Regulatory (4)

Plus 1 more regulatory pages.

Free download

Free PDF: the same MSDS verification template the Sourzi team uses to cross-reference factory documents against TSCA, REACH, AICIS, and CDR before booking.