CAS 67-64-1 · TSCA · United States of America

Acetone under TSCA

C3H6O · 丙酮

Status: Listed. Acetone is on the TSCA Inventory as a grandfathered pre-1979 substance and is currently listed as TSCA Active. No PMN is required. **Acetone is on the DEA List II of Listed Chemicals (21 CFR 1310.02(b))** as a methamphetamine-precursor solvent under the Combat Methamphetamine Epidemic Act (CMEA, 2005); transactions above threshold require DEA registration, transaction reporting, and self-certification by retailers. NO active US AD case on Chinese-origin acetone. US is structurally net-importer of acetone in some periods (driven by MMA via acetone-cyanohydrin route at AdvanSix Hopewell, BPA at Olin Stade, and pharmaceutical-grade demand) despite domestic INEOS Phenol Mobile (Alabama) cumene-route capacity.

The US acetone lane is dominated by **DEA List II compliance** under 21 CFR 1310 (DEA Form 363 registration, DEA Form 486 international-transaction reports, customer due diligence, suspicious-order reporting under CMEA 2005). NO active US AD/CVD case on Chinese-origin acetone (lighter trade-policy posture than caprolactam and AS, both with active or alleged AD case status to verify against access.trade.gov). Section 301 List 3 25% additional duty applies but is the only tariff-stack layer. TRI Form R reporting NOT required (acetone delisted from TRI 1995). US is structurally net-importer in some periods despite domestic INEOS Phenol Mobile + AdvanSix Hopewell + Altivia Petrochemicals capacity, driven by MMA via acetone-cyanohydrin route + BPA chain demand. Cumene-process phenol-acetone joint-product chain (1.6:1 ratio) couples acetone economics to phenol economics structurally; this is the dominant integrated-economics story for the US lane and mirrors the caprolactam-AS by-product chain for the EU lane.

Listing and threshold

Substance Acetone (CAS 67-64-1), C3H6O
Regime US Toxic Substances Control Act (TSCA), administered by EPA
Jurisdiction United States of America
Status Listed
Tonnage threshold CDR (Chemical Data Reporting) threshold: 25,000 lb (11,340 kg) manufactured or imported per site per year

Classifications under this regime

  • OSHA Hazard Communication Standard (HCS): GHS H225 / H319 / H336
  • OSHA PEL: 1,000 ppm (2,400 mg/m³) 8-hour TWA (29 CFR 1910.1000 Table Z-1; verify against https://www.osha.gov/annotated-pels/table-z-1)
  • NIOSH REL: 250 ppm TWA (lower than OSHA PEL)
  • **DEA List II of Listed Chemicals (21 CFR 1310.02(b))** as methamphetamine-precursor solvent
  • NOT on TSCA Section 4 test rule
  • NOT currently subject to TSCA Section 6 unreasonable-risk evaluation
  • NOT on TSCA Section 5(a)(2) Significant New Use Rule list
  • EPA RMP: NOT on RMP threshold list
  • TRI Section 313: acetone was DELISTED from TRI in 1995 (federal register 60 FR 31643); no Form R required
  • NOT on California Proposition 65 list (verify against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before relying on negative listing)
  • DOT hazardous materials regulation (49 CFR 172.101): UN 1090, Class 3, PG II
  • IARC: not classified

Restrictions and conditions of use

  • No TSCA-specific use restrictions for acetone
  • OSHA-compliant SDS and workplace HazCom training required
  • NO active US AD/CVD case on Chinese-origin acetone
  • Section 301 List 3 25% additional duty applies on Chinese-origin acetone (HS 291411)
  • **DEA List II registration and reporting requirements**: DEA Form 363 registration for handlers, DEA Form 486 transaction reports, end-use customer due diligence, suspicious-order reporting under CMEA 2005
  • NFPA 30 Flammable and Combustible Liquids Code applies for storage
  • FDA 21 CFR 175.105 approves acetone as indirect food-contact additive (adhesive component)

Importer obligations

TSCA is a self-certification regime: importers attest at customs entry that the substance is on the TSCA Inventory. The TSCA Section 13 Import Certification statement is filed via the customs broker on the entry summary (CBP Form 7501). The dominant practitioner-facing layer for acetone is **DEA List II compliance** under 21 CFR 1310: DEA Form 363 registration for any business handling acetone above threshold, DEA Form 486 transaction reports for international transactions, end-use customer due diligence, suspicious-order reporting. NO active AD/CVD case so no AD margin documentation required. Section 301 List 3 25% additional duty applies on Chinese-origin acetone but is structurally lighter than the AD + CVD + 301 stack on caprolactam (batch 14) or AS (batch 12).

Required documents

  • TSCA Section 13 Import Certification statement on customs entry
  • OSHA-compliant SDS (Safety Data Sheet) in 16-section GHS format reflecting H225 / H319 / H336 classification
  • **DEA Form 363 registration** for any party importing acetone in US commerce
  • **DEA Form 486 Import-Export Declaration** for international transactions
  • Customs entry CBP Form 7501 with HS code 291411 (acetone) and Section 301 List 3 25% duty applied
  • CDR filing every 4 years if site exceeds 25,000 lb/yr threshold (next cycle 2026)
  • NFPA 30-compliant storage tank engineering documentation for bulk receipt

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • **DEA List II compliance is the dominant practitioner overhead**. DEA Form 363 registration + Form 486 international-transaction reports + end-use customer due diligence + suspicious-order reporting under CMEA 2005
  • Section 301 List 3 25% additional duty applies (no AD on top); acetone is structurally lighter than caprolactam (batch 14) or AS (batch 12) on US tariff stack
  • TRI Form R reporting NOT required (acetone delisted from TRI 1995); this is unusual vs other industrial solvents and is operator-relevant
  • OSHA PEL 1,000 ppm vs NIOSH REL 250 ppm divergence drives workplace exposure-monitoring conservatism (most safety officers target NIOSH-equivalent)
  • Cumene-process phenol-acetone joint-product chain (1.6:1 ratio) means US imports of Chinese acetone are coupled to Chinese phenol economics and to US domestic phenol-acetone supply (INEOS Phenol Mobile, AdvanSix Hopewell) which is the swing-supply layer
  • Major US domestic acetone producers: INEOS Phenol Mobile (Alabama, cumene-route), AdvanSix Hopewell (Virginia, cumene-route), Altivia Petrochemicals Haverhill (Ohio, cumene-route)
  • US is structurally net-importer of acetone in some periods (MMA via acetone-cyanohydrin route at AdvanSix Hopewell, BPA at Olin Stade, pharmaceutical-grade demand); supplemental imports flow despite Section 301

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for acetone, see the CAS 67-64-1 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the acetone cornerstone hub covers the full sourcing chain.

For the structure and history of TSCA, see the TSCA glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

Read next

Cross-jurisdiction profile and sourcing references

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