CAS 101-68-8 · AICIS · Australia

4,4'-MDI (4,4'-methylenediphenyl diisocyanate) under AICIS

C15H10N2O2 · 4,4-亚甲基二苯基二异氰酸酯

Status: Listed. 4,4'-MDI is on the AICIS Inventory of Industrial Chemicals as a Listed Industrial Chemical. Australia adopted the GHS classification matching REACH (Resp. Sens. 1 + Carc 2 + Skin Sens. 1 + Acute Tox. 4 inhalation + STOT SE 3 + STOT RE 2). **SUSMP Schedule 6 (Poison) applies for retail mixtures above concentration cutoffs** (lighter than aniline batch 26 + EO batch 28 + PO batch 29 SUSMP Schedule 7). NOT on Australian Drug Control Act precursor list. NO active Australian AD/CVD case. Australia has limited domestic 4,4'-MDI production capacity; imports primarily flow to downstream rigid PU foam (insulation + appliance + automotive) + CASE elastomer + flexible PU foam industries. ChAFTA preferential zero-duty applies for Chinese-origin imports.

AICIS treats 4,4'-MDI as a routine listed industrial chemical with **SUSMP Schedule 6 (Poison) scheduling for retail mixtures** (lighter than aniline batch 26 + EO batch 28 + PO batch 29 SUSMP Schedule 7). The operational compliance work focuses on **workplace exposure-control + occupational asthma surveillance + medical surveillance for Resp. Sens. 1 substances**. NO active Australian AD/CVD case. ChAFTA preferential zero-duty makes Chinese-origin 4,4'-MDI competitive. Australia has **limited domestic 4,4'-MDI production**; imports primarily flow to downstream rigid PU foam + CASE elastomer + flexible PU foam industries.

Listing and threshold

Substance 4,4'-MDI (4,4'-methylenediphenyl diisocyanate) (CAS 101-68-8), C15H10N2O2
Regime Australian Industrial Chemicals Introduction Scheme (AICIS), administered by the Department of Health
Jurisdiction Australia
Status Listed
Tonnage threshold AICIS introducer registration required for any business introducing >100 kg/year of any industrial chemical

Classifications under this regime

  • Listed Industrial Chemical on AICIS Inventory
  • Australian GHS classification: Carc. 2 (H351), Acute Tox. 4 inhalation (H332), Skin Irrit. 2 (H315), Eye Irrit. 2 (H319), Resp. Sens. 1 (H334), Skin Sens. 1 (H317), STOT SE 3 (H335), STOT RE 2 (H373)
  • Signal word: DANGER. GHS pictograms: GHS07 + GHS08
  • SUSMP Schedule 6 (Poison) applies for retail mixtures above concentration cutoffs
  • NOT on Australian Drug Control Act precursor list
  • Australian Dangerous Goods Code (ADG 7.7): Class 6.1 (toxic substance) or unclassified depending on form
  • Safe Work Australia workplace exposure standard: 0.02 mg/m³ 8-hr TWA, 0.07 mg/m³ STEL (tight due to Resp. Sens. 1)
  • IARC: nitric acid itself is not separately classified; occupational exposure to strong-inorganic-acid mists containing sulfuric acid was classified IARC Group 1 (laryngeal cancer) in Monograph Volume 54 (1992) (verify the current classification and Monograph volume against https://monographs.iarc.who.int/list-of-classifications before relying on the inorganic-acid-mist read-across for nitric acid)

Restrictions and conditions of use

  • No AICIS-specific use restrictions for industrial-grade 4,4'-MDI above concentration cutoffs
  • SUSMP Schedule 6 retail packaging rules apply for retail mixtures
  • NO active Australian AD/CVD case on Chinese-origin 4,4'-MDI currently
  • WHS Regulation 2011 hazardous-chemicals handling requirements apply
  • NFPA-equivalent toxic substance storage requirements apply for bulk; ventilated storage
  • ChAFTA preferential zero-duty applies to Chinese-origin 4,4'-MDI (HS 292910)
  • **Workplace exposure-control + occupational asthma surveillance + medical surveillance** required for Resp. Sens. 1 substances

Importer obligations

The Australian importer of record must be registered with AICIS. **Workplace exposure-control + occupational asthma surveillance + medical surveillance is the dominant practitioner overhead** for Resp. Sens. 1 substances. Workplace handling SDS drives WHS hazardous-chemicals register entry. Australia has limited domestic 4,4'-MDI production; imports primarily flow to downstream rigid PU foam (insulation + appliance + automotive), CASE elastomer, flexible PU foam industries. Major Australian downstream consumers: Bayer / Covestro Australia (rigid PU foam), Dunlop Foams Australia (flexible foam), Australian automotive sector (elastomers + flexible foam).

Required documents

  • AICIS introducer registration certificate (annual)
  • WHS-compliant Safety Data Sheet (Safe Work Australia model code format) reflecting H315 / H317 / H319 / H332 / H334 / H335 / H351 / H373 classification
  • Customs entry (ICS / ABF) with HS code 292910
  • **SUSMP Schedule 6 (Poison) labelling compliance** for retail mixtures
  • ChAFTA Form CO certificate of origin for preferential treatment
  • Industrial-grade specification certificate (minimum 99% purity)
  • ADG 7.7 transport documentation (Class 6.1 or unclassified depending on form)

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • AICIS registration must be CURRENT at customs clearance
  • WHS hazardous-chemicals register entry required at handling facilities; ventilated storage for bulk
  • **Workplace exposure-control + occupational asthma surveillance + medical surveillance** required for Resp. Sens. 1 substances
  • SUSMP Schedule 6 (Poison) scheduling for retail mixtures (lighter than aniline batch 26 + EO batch 28 + PO batch 29 SUSMP Schedule 7)
  • NOT on Australian Drug Control Act precursor list
  • NO active Australian AD/CVD case on Chinese 4,4'-MDI currently
  • ChAFTA preferential zero-duty makes Chinese-origin 4,4'-MDI competitive vs Korean (Hyosung Chemicals + Kumho Mitsui), Japanese (Mitsui Chemicals + Sumitomo Chemical), Saudi (PetroRabigh + Aramco) alternatives
  • Australian end-use is limited (no major MDI production capacity domestically); imports primarily flow to downstream rigid PU foam + CASE elastomer + flexible PU foam industries

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for 4,4'-mdi (4,4'-methylenediphenyl diisocyanate), see the CAS 101-68-8 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the 4,4'-mdi (4,4'-methylenediphenyl diisocyanate) cornerstone hub covers the full sourcing chain.

For the structure and history of AICIS, see the AICIS glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

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Cross-jurisdiction profile and sourcing references

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