CAS 101-68-8 · TSCA · United States of America

4,4'-MDI (4,4'-methylenediphenyl diisocyanate) under TSCA

C15H10N2O2 · 4,4-亚甲基二苯基二异氰酸酯

Status: Listed. 4,4'-MDI is on the TSCA Inventory and is currently listed as TSCA Active. **OSHA PEL 0.02 ppm (ceiling)** at 29 CFR 1910.1000 Table Z-1 (verify against https://www.osha.gov/annotated-pels); note: tight PEL due to Resp. Sens. 1. NOT on EPA RMP threshold list. NOT on DEA scheduling. **California Proposition 65 listed as carcinogen since 4 December 2009** (verify exact listing date against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before invoicing California-distributed product). NOT on TRI Section 313 list. NO active US AD/CVD case on Chinese-origin 4,4'-MDI currently (verify against https://access.trade.gov/ before invoicing). Section 301 List 3 25% additional duty applies on Chinese-origin 4,4'-MDI (HS 292910). NOT under active TSCA Section 6 risk evaluation (verify against https://www.epa.gov/assessing-and-managing-chemicals-under-tsca). Major US domestic producers (verify each company-site pair against the producer's public website before relying): BASF Geismar Louisiana, Covestro Baytown Texas (formerly Bayer MaterialScience), Huntsman Geismar Louisiana.

The US 4,4'-MDI lane is dominated by **OSHA PEL 0.02 ppm (ceiling) compliance + Cal Prop 65 "WARNING" labelling (since 2009) + occupational asthma surveillance + medical surveillance**. NO active US AD/CVD case. Section 301 List 3 25% additional duty applies. Major US producers: BASF (Geismar Louisiana), Covestro (Baytown Texas), Huntsman (Geismar Louisiana). US is comparatively self-sufficient for MDI through domestic supply integrated upstream of aniline (batch 26) + formaldehyde (batch 18) chain. **4,4'-MDI distinguishing pattern in US lane**: tight OSHA PEL ceiling 0.02 ppm + Resp. Sens. 1 occupational asthma overhead + Cal Prop 65; lighter downstream reporting than benzene + butadiene + EO + PO (no TRI).

Listing and threshold

Substance 4,4'-MDI (4,4'-methylenediphenyl diisocyanate) (CAS 101-68-8), C15H10N2O2
Regime US Toxic Substances Control Act (TSCA), administered by EPA
Jurisdiction United States of America
Status Listed
Tonnage threshold CDR (Chemical Data Reporting) threshold: 25,000 lb (11,340 kg) manufactured or imported per site per year

Classifications under this regime

  • OSHA Hazard Communication Standard (HCS): GHS H315 / H317 / H319 / H332 / H334 / H335 / H351 / H373
  • OSHA PEL 29 CFR 1910.1000 Table Z-1: 0.02 ppm (ceiling) (tight PEL due to Resp. Sens. 1; per https://www.osha.gov/annotated-pels)
  • NIOSH REL: 0.005 ppm 8-hr TWA, 0.020 ppm STEL (occupational asthmagen; verify against https://www.cdc.gov/niosh/npg/)
  • NOT subject to TSCA Section 6 Risk Evaluation currently
  • NOT on TSCA Section 5(a)(2) Significant New Use Rule list
  • NOT on EPA RMP threshold list
  • NOT on DEA List I or List II
  • **California Proposition 65 listed as carcinogen since 4 December 2009** (verify exact listing date against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list)
  • NOT on TRI Section 313 list
  • DOT hazardous materials regulation (49 CFR 172.101): UN 2206 (some isomeric forms), Class 6.1 / unclassified depending on form
  • IARC: nitric acid itself is not separately classified; occupational exposure to strong-inorganic-acid mists containing sulfuric acid was classified IARC Group 1 (laryngeal cancer) in Monograph Volume 54 (1992) (verify the current classification and Monograph volume against https://monographs.iarc.who.int/list-of-classifications before relying on the inorganic-acid-mist read-across for nitric acid)

Restrictions and conditions of use

  • No TSCA Section 6 use restrictions currently
  • OSHA-compliant SDS and workplace HazCom training required
  • **OSHA PEL 0.02 ppm (ceiling) compliance** drives substantial workplace exposure-control overhead (occupational asthma surveillance + medical surveillance)
  • **Cal Prop 65 listing requires "WARNING"** on consumer products containing 4,4'-MDI above No-Significant-Risk-Level
  • NO active US AD/CVD case on Chinese-origin 4,4'-MDI currently
  • Section 301 List 3 25% additional duty applies on Chinese-origin 4,4'-MDI (HS 292910)
  • NOT on TRI Section 313 (lighter than benzene batch 22 + butadiene batch 27 + EO batch 28 + PO batch 29)

Importer obligations

TSCA is a self-certification regime: importers attest at customs entry that the substance is on the TSCA Inventory. The dominant practitioner-facing layer for 4,4'-MDI is **OSHA PEL 0.02 ppm (ceiling) compliance + Cal Prop 65 "WARNING" labelling + occupational asthma surveillance + medical surveillance**. NO active AD/CVD case. Section 301 List 3 25% additional duty applies. Major US domestic producers: BASF (Geismar Louisiana), Covestro (Baytown Texas), Huntsman (Geismar Louisiana). US is comparatively self-sufficient for MDI through domestic supply.

Required documents

  • TSCA Section 13 Import Certification statement on customs entry
  • OSHA-compliant SDS reflecting H315 / H317 / H319 / H332 / H334 / H335 / H351 / H373 classification
  • Customs entry CBP Form 7501 with HS code 292910 (4,4'-MDI) and Section 301 List 3 25% duty applied
  • Cal Prop 65 "WARNING" label compliance documentation for consumer-product downstream applications
  • CDR filing every 4 years if site exceeds 25,000 lb/yr threshold

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • **OSHA PEL 0.02 ppm (ceiling) compliance** drives substantial workplace exposure-control overhead with occupational asthma surveillance + medical surveillance
  • **Cal Prop 65 listing applies to all finished-product distribution to California**
  • NOT on TRI Section 313 (lighter downstream reporting overhead than benzene + butadiene + EO + PO)
  • NO active US AD/CVD case on Chinese 4,4'-MDI currently
  • Section 301 List 3 25% additional duty applies; structurally lighter than caprolactam batch 14 + acetic acid batch 19 lanes
  • Major US domestic producers: BASF (Geismar Louisiana), Covestro (Baytown Texas, formerly Bayer MaterialScience), Huntsman (Geismar Louisiana). US is comparatively self-sufficient through domestic supply
  • Production: aniline (batch 26) + formaldehyde (batch 18) → MDA → phosgenation → MDI; integrated chain economics

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for 4,4'-mdi (4,4'-methylenediphenyl diisocyanate), see the CAS 101-68-8 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the 4,4'-mdi (4,4'-methylenediphenyl diisocyanate) cornerstone hub covers the full sourcing chain.

For the structure and history of TSCA, see the TSCA glossary entry.

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Cross-jurisdiction profile and sourcing references

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