CAS 75-05-8 · K-REACH · Republic of Korea

Acetonitrile under K-REACH

CH3CN · 乙腈

Status: Registered. Acetonitrile is registered under K-REACH. **Korea TCCA Toxic Chemicals list scheduling-potential** (verify against the current TCCA Toxic Chemicals list at https://www.nics.go.kr/ https://www.nics.go.kr/ before relying; flammable + acute-toxicity + cyanide-metabolite profile). **Drug Precursor scope determination under Korean Act on Control of Narcotics MFDS may apply to acetonitrile in PCP / methamphetamine synthesis matrix** (verify against https://www.mfds.go.kr/ before invoicing). NO active Korean AD/CVD case on Chinese-origin acetonitrile. KCFTA preferential zero-duty applies for Chinese-origin imports. Korea is a significant acetonitrile consumer market (Korean Samsung SDI + LG Energy Solution + SK On lithium-ion battery electrolyte + pharmaceutical analytical labs + petrochemical extraction-distillation) with both domestic production (Asahi Kasei + Korean petrochemical-byproduct) and Chinese-origin import dependency.

K-REACH treats acetonitrile as a registered substance with **TCCA Toxic Chemicals Handling Permit overlay-potential + Drug Precursor scope-determination overlay (Korean Act on Control of Narcotics MFDS)**. KCFTA preferential zero-duty. NO active Korean AD/CVD. **Korean Samsung SDI + LG Energy Solution + SK On lithium-ion battery electrolyte + pharmaceutical analytical labs + petrochemical extraction-distillation downstream chains**. **Acetonitrile distinguishing pattern across all 5 regimes**: Production primarily as byproduct of acrylonitrile manufacture (SOHIO ammoxidation of propylene); 2009 global shortage when acrylonitrile capacity reduced is the structural risk; metabolised in body to cyanide (basis for acute-toxicity classification); Flam. Liq. 2 H225 (flash point ~2°C) + Acute Tox. 4 oral / dermal / inhalation + Eye Irrit. 2 across all jurisdictions; IARC Monograph Volume 71 (1999) Group 3 (not classifiable); UN 1648 Class 3 PG II flammable liquid across all transport regimes (ADR + DOT 49 CFR + GB 12268 + ADG + Korean DOT-equivalent); OSHA PEL 40 ppm + 60 ppm STEL (no skin notation) per 29 CFR 1910.1000 Table Z-1 + NIOSH REL 20 ppm + skin + ACGIH TLV-TWA 20 ppm + skin + Korean MoEL OEL 20 ppm + skin + Safe Work Australia WES 40 ppm + 60 ppm STEL + skin; **NOT on EU Drug Precursors Reg 273/2004 + Reg 2015/1011 + NOT federal-level US DEA scheduled (state-level monitoring exists) + Drug Precursor scope-determination scope-potential under Australian Crimes (Drug Precursors) Act 2008 + Korean Act on Control of Narcotics + China State Council 易制毒化学品管理条例 NOT-scheduled-at-acetonitrile-level**; **HPLC + UPLC mobile phase reagent ~30 to 40% of global consumption (research + pharmaceutical analytical labs) + lithium-ion battery electrolyte solvent (emerging large-use, Samsung SDI + LG Energy Solution + SK On Korean battery cell makers, CATL + BYD Chinese cell makers) + pharmaceutical intermediate (vitamin B1 + thiamine + acrylonitrile-derived drug intermediates) + extraction solvent (butadiene + olefin extractive distillation in petrochemical refining) + organic synthesis solvent downstream chains**; major non-Chinese producers INEOS (Texas Lima OH + Houston TX) + Asahi Kasei (Japan Mizushima) + Mitsubishi Chemical (Japan) + Showa Denko (Japan); **China major acetonitrile producer + exporter** (Wanhua Chemical Yantai Shandong + Yancheng Jiangsu post-Borsodchem acquisition + Sinopec Anqing Anhui + Jiangsu Sailboat Petrochemical + Shandong Lianhuan + Tianhua Group).