CAS 75-05-8 · TSCA · United States of America

Acetonitrile under TSCA

CH3CN · 乙腈

Status: Active. Acetonitrile is on the TSCA Active Inventory. **NOT typically Cal Prop 65 listed at acetonitrile level** (verify against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before relying). **DEA + DOJ: acetonitrile is NOT on DEA List I or List II at the federal level** (verify against https://www.deadiversion.usdoj.gov/ before relying); some state-level controls exist where acetonitrile is monitored as solvent in clandestine drug synthesis (PCP + methamphetamine synthesis matrix). **EPA Clean Air Act Section 112 HAP: acetonitrile NOT specifically listed** (verify against https://www.epa.gov/haps before relying). NO active US AD/CVD case on Chinese-origin acetonitrile currently (verify against access.trade.gov before invoicing).

Acetonitrile is TSCA-Active. OSHA PEL 40 ppm 8-hr TWA + 60 ppm STEL per 29 CFR 1910.1000 Table Z-1 (cyanide-metabolite mechanism). IARC Volume 71 (1999) Group 3. **DEA NOT scheduled at federal level** (state-level monitoring exists). DOT UN 1648 Class 3 PG II. EPA RCRA U003 listed waste. NO active US AD/CVD. **HPLC + UPLC mobile phase + lithium-ion battery electrolyte + pharmaceutical intermediate + extraction solvent + organic synthesis solvent downstream chains**.

Listing and threshold

Substance Acetonitrile (CAS 75-05-8), CH3CN
Regime US Toxic Substances Control Act (TSCA), administered by EPA
Jurisdiction United States of America
Status Active
Tonnage threshold TSCA Section 8(a) Chemical Data Reporting (CDR) at >25,000 lb/year per US site

Classifications under this regime

  • TSCA Active Inventory
  • OSHA PEL: 40 ppm 8-hr TWA + 60 ppm STEL per 29 CFR 1910.1000 Table Z-1 (no skin notation at OSHA) (verify against https://www.osha.gov/annotated-pels before relying)
  • NIOSH REL: 20 ppm 8-hr TWA + skin notation (verify against current https://www.cdc.gov/niosh/npg/)
  • ACGIH TLV-TWA: 20 ppm + skin notation (verify against current ACGIH TLV documentation at https://www.acgih.org/ before relying)
  • IARC Volume 71 (1999) Group 3 (not classifiable) (verify against https://monographs.iarc.who.int/ before relying)
  • **NOT typically Cal Prop 65 listed** (verify against https://oehha.ca.gov/proposition-65/proposition-65-list before relying)
  • DOT 49 CFR: UN 1648 ACETONITRILE Class 3 PG II flammable liquid
  • **DEA NOT on List I / List II at federal level** (verify against https://www.deadiversion.usdoj.gov/ before relying; state-level monitoring exists in some jurisdictions)
  • EPA RCRA: acetonitrile is U-listed waste (U003) when discarded as commercial chemical product (verify against ecfr.gov 40 CFR 261.33)

Restrictions and conditions of use

  • NO active US AD/CVD case on Chinese-origin acetonitrile currently (verify against access.trade.gov before invoicing)
  • OSHA PEL 40 ppm 8-hr TWA + 60 ppm STEL (29 CFR 1910.1000 Table Z-1)
  • EPA RCRA U003 listed waste when discarded as commercial chemical product
  • EPA TRI reporting for acetonitrile (verify against https://www.epa.gov/toxics-release-inventory-tri-program)
  • No CBP-specific restriction beyond HS 292690

Importer obligations

TSCA Section 13 import certification (positive). DOT 49 CFR Class 3 PG II flammable liquid transport documentation. Major non-Chinese producers: INEOS (Texas Lima OH + Houston TX), Asahi Kasei (Japan Mizushima), Mitsubishi Chemical (Japan), Showa Denko (Japan). Major Chinese exporters: Wanhua Chemical (Yantai Shandong + Yancheng Jiangsu) + Sinopec Anqing (Anhui) + Jiangsu Sailboat Petrochemical + Shandong Lianhuan + Tianhua Group.

Required documents

  • TSCA Section 13 import certification
  • CBP entry HS 292690 (other nitrile-function compounds)
  • SDS (Flam. Liq. 2 + Acute Tox. 4 oral / dermal / inhalation + Eye Irrit. 2 + cyanide-metabolite mechanism)
  • DOT shipping papers UN 1648 Class 3 PG II flammable liquid
  • EPA RCRA U003 documentation where discarded as commercial chemical product

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • NO active US AD/CVD case on Chinese-origin acetonitrile currently
  • OSHA PEL 40 ppm 8-hr TWA + 60 ppm STEL (29 CFR 1910.1000 Table Z-1)
  • **DEA NOT scheduled at federal level (state-level monitoring exists)**
  • IARC Volume 71 (1999) Group 3
  • EPA RCRA U003 listed waste
  • DOT UN 1648 Class 3 PG II flammable liquid (cyanide-metabolite mechanism)
  • **HPLC + UPLC mobile phase ~30 to 40% (US pharmaceutical + research analytical labs) + lithium-ion battery electrolyte solvent (emerging) + pharmaceutical intermediate + extraction solvent + organic synthesis solvent downstream chains**

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for acetonitrile, see the CAS 75-05-8 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the acetonitrile cornerstone hub covers the full sourcing chain.

For the structure and history of TSCA, see the TSCA glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

Read next

Cross-jurisdiction profile and sourcing references

Referenced in

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