CAS 7681-49-4 · REACH · European Union

Sodium fluoride (NaF) under REACH

NaF · 氟化钠

Status: Registered. Sodium fluoride is fully registered under REACH. **Distinguishing pattern: Production via neutralisation of HF batch 85 with sodium hydroxide batch 1 or sodium carbonate batch 36 (HF + NaOH → NaF + H2O) + alongside fluorine chain feedstock for fluoride-chemistry downstream + toothpaste / dental caries-prevention agent (~30% of consumption) plus municipal water-fluoridation plus glass / enamel flux plus pesticide / wood-preservative plus pharma plus rust-inhibitor plus electroplating-additive downstream chains + moderate hazard profile (Acute Tox. 3 oral + STOT RE 2 (skeletal fluorosis at chronic high exposure) + Skin Irrit. 2 + Eye Irrit. 2 per harmonised CLP entry; verify exact harmonised classification against ECHA Annex VI to CLP Table 3.1 before relying).** NOT SVHC. NOT Annex XIV. NO active EU AD case on Chinese-origin sodium fluoride currently (verify against EUR-Lex https://eur-lex.europa.eu/ before invoicing).

Sodium fluoride is fully REACH-registered with **moderate hazard profile** (Acute Tox. 3 oral + STOT RE 2 + Skin Irrit. 2 + Eye Irrit. 2). NOT SVHC, NOT Annex XIV. NO active EU AD. **Toothpaste caries-prevention + water-fluoridation + glass / enamel flux + pesticide + pharma downstream chains**. EU Cosmetic Products Regulation Annex III F-cap.

Listing and threshold

Substance Sodium fluoride (NaF) (CAS 7681-49-4), NaF
Regime EU Regulation (EC) No 1907/2006: Registration, Evaluation, Authorisation and Restriction of Chemicals
Jurisdiction European Union (EU-27 plus EEA: Iceland, Liechtenstein, Norway)
Status Registered
Tonnage threshold Registration required for any importer or manufacturer placing >1 t/year on the EU market

Classifications under this regime

  • Acute Tox. 3 (oral): H301 per harmonised CLP (verify against ECHA Annex VI to CLP Table 3.1 before relying)
  • STOT RE 2 (skeletal fluorosis at chronic high exposure): H373
  • Skin Irrit. 2: H315 + Eye Irrit. 2: H319
  • GHS pictograms: GHS06 (skull and crossbones), GHS07 (exclamation), GHS08 (health hazard)
  • IARC: Not classified
  • NOT subject to Drug Precursors or Explosives Precursors scheduling
  • ADR / RID: UN 1690 Class 6.1 PG III (toxic solid)
  • **EU Pharmacopoeia monograph** for pharma-grade sodium fluoride caries-prevention agent (verify monograph reference against EDQM / Ph. Eur. before relying)
  • **EU Cosmetic Products Regulation Annex III** caps fluoride concentration in toothpaste at 0.15% F (1500 ppm) for adult-grade and 0.10% F (1000 ppm) for child-grade (verify against EU Reg (EC) No 1223/2009 Annex III at https://eur-lex.europa.eu/ before relying)

Restrictions and conditions of use

  • NOT on REACH Annex XIV (verify against ECHA https://echa.europa.eu/authorisation-list)
  • NOT classified as SVHC (verify against ECHA https://echa.europa.eu/candidate-list-table)
  • NOT subject to any Annex XVII restriction
  • NO active EU AD case on Chinese-origin sodium fluoride currently (verify against EUR-Lex https://eur-lex.europa.eu/ before invoicing)
  • **EU Cosmetic Products Regulation Annex III caps fluoride in toothpaste at 0.15% F adult / 0.10% F child** (verify against EU Reg (EC) 1223/2009 Annex III)
  • NOT in CBAM Phase 1 scope

Importer obligations

A non-EU producer cannot register directly under REACH. The EU importer of record must hold a registration or rely on an Only Representative (OR). Major Chinese sodium fluoride producers (typically integrated with HF / fluorspar operations): Sinochem Lantian, Juhua Group Quzhou, Dongyue Group Tantai Shandong, Sanmei Chemical, Multifluoro Chemicals; verify each producer-site pair against the producer's public website before relying.

Required documents

  • REACH registration number on EU side
  • SDS (Acute Tox. 3 oral + STOT RE 2 + Skin Irrit. 2 + Eye Irrit. 2)
  • Customs entry HS code 282619 (sodium fluoride)
  • ADR documentation for UN 1690 Class 6.1 PG III
  • Pharma-grade Ph. Eur. + EU Cosmetic Products Regulation Annex III certifications where applicable

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • **Production: HF batch 85 + NaOH batch 1 or Na2CO3 batch 36 → NaF + H2O**
  • **Alongside fluorine chain (HF batch 85 + NaF + downstream fluoride-chemistry)**
  • Acute Tox. 3 oral + STOT RE 2 (skeletal fluorosis chronic high exposure) + Skin Irrit. 2 + Eye Irrit. 2
  • NOT SVHC, NOT Annex XIV, NO active EU AD
  • **Toothpaste / dental caries-prevention ~30% + municipal water-fluoridation + glass / enamel flux + pesticide / wood-preservative + pharma + rust-inhibitor + electroplating-additive downstream chains**
  • **EU Cosmetic Products Regulation Annex III caps F in toothpaste at 0.15% adult / 0.10% child**
  • Major Chinese producers (HF / fluorspar integrated): Sinochem Lantian, Juhua Group Quzhou, Dongyue Group Tantai Shandong, Sanmei Chemical, Multifluoro Chemicals

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for sodium fluoride (naf), see the CAS 7681-49-4 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the sodium fluoride (naf) cornerstone hub covers the full sourcing chain.

For the structure and history of REACH, see the REACH glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

Read next

Cross-jurisdiction profile and sourcing references

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