CAS 7681-49-4 · TSCA · United States of America

Sodium fluoride (NaF) under TSCA

NaF · 氟化钠

Status: Listed. Sodium fluoride is on the TSCA Inventory and currently listed as TSCA Active. **OSHA PEL for fluoride compounds at 29 CFR 1910.1000 Table Z-1: 2.5 mg/m3 8-hr TWA expressed as F (verify against https://www.osha.gov/annotated-pels before relying); NIOSH REL: 2.5 mg/m3 8-hr TWA (verify against cdc.gov/niosh).** NOT on EPA RMP threshold list. NOT on DEA scheduling. **Sodium fluoride IS on the California Proposition 65 list for developmental toxicity** (listing date in the early 1990s; verify exact listing date and endpoint against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before relying). NO active US AD/CVD case on Chinese-origin sodium fluoride currently (verify against https://access.trade.gov/ before invoicing). Section 301 List 3 25% additional duty applies on Chinese-origin sodium fluoride (HS 282619) (verify against current USTR Section 301 schedule before invoicing). **FDA recognises sodium fluoride as an OTC anti-caries active under 21 CFR 355 Anticaries Drug Products Final Monograph** (verify against https://www.ecfr.gov/ before relying); USP / NF monograph applies for pharma-grade. **EPA FIFRA registers sodium fluoride as a wood-preservative pesticide active** (verify current FIFRA registration status against https://www.epa.gov/pesticide-registration before relying). Major US domestic producers: Solvay Specialty Phosphates US operations, ICL Performance Products US operations (verify each company-site pair against the producer's public website before relying).

US sodium fluoride lane: **OSHA PEL 2.5 mg/m3 + NIOSH REL 2.5 mg/m3 + FDA OTC anti-caries active 21 CFR 355 + EPA FIFRA wood-preservative pesticide active + Section 301 List 3 + UN 1690 Class 6.1 PG III**. **On Cal Prop 65 for developmental toxicity** (verify exact date against OEHHA before relying). NO active US AD/CVD. Major US producers: Solvay Specialty Phosphates + ICL Performance Products.

Listing and threshold

Substance Sodium fluoride (NaF) (CAS 7681-49-4), NaF
Regime US Toxic Substances Control Act (TSCA), administered by EPA
Jurisdiction United States of America
Status Listed
Tonnage threshold CDR threshold: 25,000 lb manufactured or imported per site per year

Classifications under this regime

  • OSHA HCS: Acute Tox. 3 oral + STOT RE 2 + Skin Irrit. 2 + Eye Irrit. 2
  • OSHA PEL for fluoride compounds: 2.5 mg/m3 8-hr TWA as F at 29 CFR 1910.1000 Table Z-1 (verify against https://www.osha.gov/annotated-pels)
  • NIOSH REL: 2.5 mg/m3 8-hr TWA (verify against cdc.gov/niosh)
  • NOT subject to TSCA Section 6 Risk Evaluation
  • NOT on EPA RMP threshold list
  • NOT on DEA List I or List II
  • On California Proposition 65 for developmental toxicity (verify exact listing date against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before relying)
  • DOT 49 CFR 172.101: UN 1690 Class 6.1 PG III
  • **FDA OTC anti-caries active 21 CFR 355 Anticaries Drug Products Final Monograph** (verify against https://www.ecfr.gov/)
  • **USP / NF monograph** applies for pharma-grade
  • **EPA FIFRA wood-preservative pesticide active** (verify current FIFRA registration status against https://www.epa.gov/pesticide-registration)
  • IARC: Not classified

Restrictions and conditions of use

  • NO active US AD/CVD case on Chinese-origin sodium fluoride currently
  • Section 301 List 3 25% additional duty applies on Chinese-origin sodium fluoride (HS 282619)
  • OSHA PEL 2.5 mg/m3 8-hr TWA as F + NIOSH REL 2.5 mg/m3
  • **FDA OTC anti-caries active 21 CFR 355**
  • **EPA FIFRA wood-preservative pesticide active**

Importer obligations

TSCA self-certification regime. Major US producers: Solvay Specialty Phosphates US operations, ICL Performance Products US operations.

Required documents

  • TSCA Section 13 Import Certification on customs entry
  • OSHA SDS (Acute Tox. 3 oral + STOT RE 2 + Skin Irrit. 2 + Eye Irrit. 2)
  • CBP Form 7501 with HS 282619 + Section 301 List 3 25% duty
  • CDR filing every 4 years
  • DOT documentation for UN 1690 Class 6.1 PG III
  • FDA 21 CFR 355 + USP / NF certifications for OTC anti-caries / pharma grades
  • EPA FIFRA registration where placed as wood-preservative pesticide active

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • OSHA PEL 2.5 mg/m3 + NIOSH REL 2.5 mg/m3 8-hr TWA as F
  • NO active US AD/CVD case
  • Section 301 List 3 25% additional duty applies
  • **FDA OTC anti-caries active 21 CFR 355 Anticaries Drug Products Final Monograph**
  • **EPA FIFRA wood-preservative pesticide active**
  • Major US producers: Solvay Specialty Phosphates + ICL Performance Products

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for sodium fluoride (naf), see the CAS 7681-49-4 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the sodium fluoride (naf) cornerstone hub covers the full sourcing chain.

For the structure and history of TSCA, see the TSCA glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

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Free PDF: the same MSDS verification template the Sourzi team uses to cross-reference factory documents against TSCA, REACH, AICIS, and CDR before booking.